Tollovid: Brief Introduction
Tollovid® is a botanically – sourced dietary cleansing supplement sold directly to consumers in the United States and certain international markets. The recommended cleansing dose to support 3CL protease inhibition is 3 capsules 4 times daily until achieving desired results. The recommended cleansing dose to maintain desired 3CL protease levels is 1 capsule 2 times daily. One Tollovid® is delivered in capsule format and contains Lithospermum Erythrorhizon(sometimes called Gromwell) root extract and is qualified for 3CL protease (3CLpro, Main protease, Mpro, NSP5) inhibitory activity.
The main botanical ingredients of Tollovid® are derived from organic extracts of Lithospermum Erythrorhizon roots (Gromwell Extract), a plant species that is a member of the Lithospermeae tribe of the Boraginaceae plant family. Lithospermeae play important roles in Traditional Chinese Medicine and have a long history of safety and tolerability.
NATURAL SOLUTION:Tollovid® is a botanically-sourced commercial product that is available as a supplement and sold directly to consumers in the US and certain European markets, and has a Certificate of Free Sale.
Classification of Lithospermum and Arnebia (From NCBI: txid 34254 and 37312)
3 capsules, 4x daily
Main desired 3CL levels
KEY TAKEAWAYS: 12 capsules/day contain up to approximately
<5mg of gromwell root
(Lithospermum Erythrorhizon) powder.
TOXICOLOGY, PK, ADME PUBLICATIONS
GR Extract Published Studies
STUDIES WITH GR EXTRACTS
PK data are available from studies in beagles indicate how Lithospermum extract accumulates with repeated dosing over the course of 28 days.
Finally, Zhang et al (2020) reviewed studies concerning the distribution, absorption, and elimination of an index analyte of root. The results indicated: (In mice)... was mainly distributed in the stomach and intestine, secondarily in the gallbladder, liver, kidneys, lungs, and least in the brain and spinal cord. The cumulative excretion rate of feces and urine was nearly 80% within 48 h, mainly through fecal excretion. These results indicated that acetylshikonin had a wide distribution and poor absorption in mice. The binding rate of acetylshikonin to human plasma proteins was high. In general, acetylshikonin has a wide distribution, poor absorption, and high binding rate to human plasma proteins.
Tollovid® is manufactured at American Health Formulations (AHF - www.ahfvitamins.com), a cGMP manufacturer of dietary supplement and Medical Food products in Hauppauge, New York. AHF is a member of the American Botanical Manufacturing Association. Tollovid® is Made in the USA.
The only known common side effect of Tollovid® is that it causes stool to turn dark. This is because some of the ingredients are also used as natural dyes in food, specifically for dark purple. This is not associated with any other side effects.