3CL Protease Inhibitors*

The science behind Tollovid

*Based on in vitro data

The Potential Key to Combating the Virus Life Cycle

The Virus Life Cycle

The stages in the virus life cycle include binding, entry, breakdown of proteins into smaller polypeptides or amino acids, and RNA replication. Viruses contain a single strand of RNA (or DNA) wrapped in a protein envelope. The RNA contains the genetic instructions the virus needs to make copies of itself. Viruses spread with a simple two-step process:

  • Step 1
  • Step 2

I. Break into a healthy cell

II. Hijack the cell’s own mechanisms to make copies of itself

Studies have shown, however, that by using protease inhibitors*, we can stop the virus’ ability to replicate itself, halting the spread in it tracks. To understand how this is done, let’s take a closer look at the infection lifecycle:

*Based on in vitro data

1. Binding & Entry

First, the infection must get inside the cell. Every infection does this slightly differently, but most use their signature “spikes” to fuse themselves to a cell’s outer membrane and then squeeze their way inside.

2. Polypeptides

Once inside, the RNA instructs the cell to make a long polypeptide containing special enzymes. This long protein must be cut apart for the infection to replicate. To accomplish this, the infection encodes a special ‘scissors’, called 3CL protease, which cuts up the polypeptide into the different enzymes that then become functional.

3. Cutting & Replication

Before these enzymes can start working, they need to be separated from each other. The protease enzyme acts like a pair of scissors, cutting the polypeptide up into the different enzymes that then become functional.

4. 3CL Inhibitors

3CL Protease Inhibitors*, like Tollovid, are designed to tightly bind to the protease enzyme, blocking its ability to cut. This shuts down the entire infection-cloning apparatus, leaving it unable to replicate.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Sale Off