Preprint of Data from 1st 100 Participants in IRB-waived Research Study of Tollovid + Long COVID

Preprint of Data from 1st 100 Participants in IRB-waived Research Study of Tollovid + Long COVID

New York, NY, and Tel Aviv, ISRAEL, Aug. 19, 2022 (GLOBE NEWSWIRE) -- via NewMediaWire -- Todos Medical, Ltd. (OTCQB: TOMDF), a comprehensive medical diagnostics and related solutions company, today announced that its majority-owned joint venture 3CL Pharma Ltd. reported the preprint in ResearchGate of results from the first 100-participant study from an IRB-waived market research study entitled “The Value of 3CL Protease Inhibitor Supplementation in Long Haul Syndrome Patients?” overseen by Dr. Dorit Arad in concert with Andrew A. Blumenthal, RN ADS. Participants in the study are primarily patients with Post-Acute Sequelae of COVID (PASC, or “Long COVID”) as well as participants with acute COVID infection. The results to date indicate the participants appear to experience benefit after supplementation with 3CL protease inhibitor immune support supplement Tollovid™. The publication preprint can be viewed at:


In moderate to severe acute COVID-19 and Long Haul Syndrome (LHS), innate and adaptive immunological dysregulation is frequently observed and can persist for months, leading to a significant decline in clinical status and quality of life for many individuals. One hallmark of an over-exuberant immunological response is cytokine hyperactivity ('cytokine storm') that can lead to severe acute respiratory distress syndrome in certain patients. Reduced immunopathology and clinical resolution of the acute disease, on the other hand, appear to be associated with a powerful early innate antiviral response coupled with viral neutralization in such patients. The mechanisms by which the SARS-CoV-2 virus may subvert the host immune response are the subject of focused research in an effort to define virally-encoded factors that might be targeted for therapeutic intervention. One such target is the 3CL protease (3CLpro, Main protease, Mpro, Nsp5), sometimes referred to as the 'Achilles heel' of the SARS-CoV-2 virus. 3CLpro is essential to viral replication, and can also have direct, deleterious effects on the host's immune response, potentially via NEMO inactivation, thereby impacting the ability to resolve infections. Viral protease inhibitors have been used in several licensed oral medications and are well-validated therapeutic targets for the treatment of hepatitis C virus (HCV) and the human immunodeficiency virus (HIV). Indeed, pharmaceutical 3CLpro inhibitors are currently the most prescribed antiviral therapy for COVID-19. Here, through a series of 104 case study respondents in an IRB-waived market research self-reported questionnaire, we highlight emerging evidence concerning positive clinical and immunological impacts of supplementation with Tollovid, a natural, botanically-based immune cleanse/support dietary supplement with potent 3CL protease inhibitory activity in vitro, first reported here, in patients suffering from Acute COVID and LHS-related symptoms.

About Todos Medical Ltd.

Founded in Rehovot, Israel with offices in New York City, Todos Medical Ltd. (OTCQB: TOMDF) engineers life-saving diagnostic solutions for the early detection of a variety of cancers. The Company's state-of-the-art and patented Todos Biochemical Infrared Analyses (TBIA) is a proprietary cancer-screening technology using peripheral blood analysis that examines cancer's influence on the immune system, looking for biochemical changes in blood mononuclear cells and plasma. Todos’ two internally developed cancer-screening tests, TMB-1 and TMB-2 have received a CE mark in Europe. Todos recently acquired U.S.-based medical diagnostics company Provista Diagnostics, Inc. to gain rights to its Alpharetta, Georgia-based CLIA/CAP certified lab currently performing PCR COVID testing, Long COVID Panel analyses, and Provista's proprietary commercial-stage Videssa® breast cancer blood test. More information on Provista is available at

Todos is also developing blood tests for the early detection of neurodegenerative disorders, such as Alzheimer's disease. The Lymphocyte Proliferation Test (LymPro Test™) is a diagnostic blood test that determines the ability of peripheral blood lymphocytes (PBLs) and monocytes to withstand an exogenous mitogenic stimulation that induces them to enter the cell cycle. It is believed that certain diseases, most notably Alzheimer's disease, are the result of compromised cellular machinery that leads to aberrant cell cycle re-entry by neurons, which then leads to apoptosis. LymPro is unique in the use of peripheral blood lymphocytes as a surrogate for neuronal cell function, suggesting a common relationship between PBLs and neurons in the brain.

Todos formed the Israeli-based majority-owned joint venture 3CL Pharma, Ltd with NLC Pharma in March of 2022 to consolidate all of the intellectual property surrounding 3CL protease – based diagnostic testing and development of 3CL protease botanical and pharmaceutical inhibitors that target a fundamental reproductive mechanism of coronaviruses. 3CL Pharma, through Todos’ brand, has commercialized the 3CL protease inhibitor immune support dietary supplement Tollovid™ in the United States, is developing the dual mechanism 3CL protease inhibitor and anti-cytokine therapeutic drug candidate Tollovir™, while also developing the 3CL protease diagnostic TolloTest™.

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